Lineage Tracing

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Lineage Tracing

Lineage tracing is the identification of all progeny of a single cell. Although its origins date back to developmental biology of invertebrates in the 19(th) century, lineage tracing is now an essential tool for studying stem cell properties in adult mammalian tissues. Lineage tracing provides a powerful means of understanding tissue development, homeostasis, and disease, especially when it is ...

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Tracing Lineage Beyond Relational Operators

Tracing the lineage of data is an important requirement for establishing the quality and validity of scientific data. Recently, the problem of data provenance has been increasingly addressed in database research. This work has been limited to the lineage of data as it is manipulated using relational operations within an RDBMS. While this captures a very important aspect of scientific data proce...

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Tracing Lineage Beyond Relational Operators

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Lineage-tracing methods and the kidney

The kidney is a complex organ with over 30 different cell types, and understanding the lineage relationships between these cells is challenging. During nephrogenesis, a central question is how the coordinated morphogenesis, growth, and differentiation of distinct cell types leads to development of a functional organ. In mature kidney, understanding cell division and fate during injury, regenera...

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ژورنال

عنوان ژورنال: Cell

سال: 2012

ISSN: 0092-8674

DOI: 10.1016/j.cell.2012.01.002